BPC 157 is a pentadecapeptide, composed of 15 amino acids, that has demonstrated potential to increase testosterone levels in animal studies. However, human trials are still needed to conclusively determine if BPC 157 can reliably and safely increase testosterone in humans.
Key points about BPC 157 and testosterone:
- BPC 157 has been shown in rat studies to protect testicular tissue from damage and preserve testosterone production after testicular torsion injury.
- A rat study found BPC 157 administration countered the decrease in testosterone levels caused by NSAID drugs.
- BPC 157 accelerates healing of injured muscle tissue. By supporting faster recovery, it may help maintain higher testosterone levels that drop after injuries.
- By reducing systemic inflammation, BPC 157 may help counteract drops in testosterone that can result from chronic inflammatory conditions.
- No human studies have yet evaluated the effects of BPC 157 supplementation on testosterone levels. Animal research cannot prove BPC 157 will reliably increase testosterone in humans.
Animal Research on BPC 157 and Testosterone
- In a rat model of testicular torsion injury, BPC 157 administration reduced damage to testicular tissue and resulted in higher blood testosterone levels, reduced oxidative stress, and stronger antioxidant defenses compared to untreated rats.
- Another rat study found that giving BPC 157 could counteract the decrease in serum testosterone levels caused by two common NSAID drugs (ketoprofen and diclofenac).
- BPC 157 has been found in rat studies to accelerate the healing of injured muscle tissue. By helping heal exercise-induced muscle damage more quickly, it may aid recovery of normal testosterone fluctuations that often dip in the days after muscle injuries.
- As a systemic anti-inflammatory agent, BPC 157 suppresses inflammatory cytokines. Chronic inflammation is associated with lower testosterone. By regulating inflammatory pathways, BPC 157 may attenuate inflammation-induced drops in testosterone.
Considerations for Humans
- Despite promising animal research, no published human studies have evaluated whether BPC 157 supplementation actually increases testosterone or offsets conditions known to reduce testosterone.
- BPC 157 has only been tested in humans in a few small studies analyzing its effects on healing ulcers. More human research is needed to understand its effects on hormones.
- The rat studies used injections for administering BPC 157. In human supplements, BPC 157 is only available as oral capsules, which may not effectively replicate dosing from injections in rat studies.
- Dosage and cycles for humans are very unclear due to lack of clinical trials. Optimal protocols are unknown.
- Long-term safety has not been evaluated. Until more is known, consult a doctor before considering use of BPC 157.
Harmony Hormone Center specializes in testing hormone levels and developing customized treatment plans to help patients optimize hormones like testosterone for improved health, wellbeing and performance. Our clinic offers cutting-edge therapies, nutraceuticals and protocols tailored for your unique biology and lifestyle needs. Consult with our
hormone therapy experts to determine if BPC 157 or other modalities are right for your goals. We accept most major insurances and provide affordable payment options.
